Claisen-Schmidt Condensation

Schematic representation of the Claisen-Schmidt Condensation.
Mechanism of the Claisen-Schmidt Condensation
Mechanism of the Claisen-Schmidt Condensation
Sample reactions
intermediate structure intermediate structure
NaOH
MeOH
RT, 48 h, 96%
intermediate structure
intermediate structure intermediate structure
H3PO4
80 °C, , 82%
intermediate structure
intermediate structure
(CH2O)3, PhNHMe.TFA
Dioxane
45%
"The yield was 90 % brsm."
intermediate structure
intermediate structure
TsOH
PhH
80 °C, , 75% (3 steps)
intermediate structure
intermediate structure
TsOH
PhH
Reflux, 4 h, 78%
intermediate structure
intermediate structure
NaOH, Dibenzo-18-crown-6
PhH
Reflux, , 96%
intermediate structure
intermediate structure
Piperidine, AcOH
PhMe
Reflux, 48 h, 41%
intermediate structure
intermediate structure intermediate structure
NaOH
EtOH, H2O
RT, 15 h, 83%
intermediate structure
intermediate structure intermediate structure
Mg(OMe)2
PhMe
Reflux, 2.5 h, 52%
intermediate structure